癌变·畸变·突变 ›› 2005, Vol. 17 ›› Issue (3): 187-189.doi: 10.3969/j.issn.1004-616x.2005.03.016

• 检测研究 • 上一篇    下一篇

山萸肉醇提液的致突变性

张慧珍;宋春花;杨继要;呼世斌;吴逸明   

  1. 郑州大学医学院公共卫生学院, 河南 郑州 450052
  • 收稿日期:2004-09-13 修回日期:2004-10-28 出版日期:2005-05-30 发布日期:2005-05-30
  • 通讯作者: 张慧珍

Mutagenicity of the Matter Extracted from the Pulp of Cornus by Ethanol

ZHANG Hui-zhen;SONG Chun-hua;YANG Ji-yao;HU Shi-bin;WU Yi-ming   

  1. Department of Environmental Health, College of Public Health Zhengzhou University,Zhengzhou 450052,Henan,China
  • Received:2004-09-13 Revised:2004-10-28 Online:2005-05-30 Published:2005-05-30
  • Contact: ZHANG Hui-zhen

摘要: 背景与目的: 从遗传学角度评价山茱萸果肉醇提物的潜在危害性,为山茱萸开发为保健功能性食品提供科学依据。材料与方法: 采用小鼠睾丸染色体畸变试验,小鼠骨髓微核实验以及小鼠精子畸形实验方法。 结果: 山萸肉醇提物诱发小鼠睾丸染色体畸变实验,诱发小鼠精子畸形实验以及微核实验结果显示,各剂量组与阴性对照相比较,差异均无显著性。结论:山萸肉醇提液对实验动物均没有染色体与细胞水平上的损伤作用,结合其它毒理学资料可以考虑作为新食品资源利用。

关键词: 山萸肉, 醇提液, 致突变

Abstract: BACKGROUND & AIM: To check the mutagenicity of the matter extracted from the Pulp of cornus by ethanol. MATERIAL AND METHODS: Chromosome aberration test, micronucleus test of bone marrow cell and sperm shape abnormality test in mice were used in this study. RESULTS: The test result shows that: there have no significant difference between the matter extracted from the pulp of cornus by ethanol and negative control, but has significant difference to positive control. CONCLUSION: The matters extracted has no damage effect on the chromosome and cell levels. It provides science proof on exploiting functional health food of cornus of ficinalis sieb.et Zucc.

Key words: pulp of cornus, the matter extracted by ethanol, mutagenicity